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Description

Adults and children aged 12 years and over: Take 10-20 ml (two to four 5ml spoonfuls) after meals and at bedtime, up to four times a day

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For athletes, this means that the clearest upside is the "soft-tissue housekeeping" (i.e., skin and connective tissue) that may complement their recovery

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Phase 3 trials, including NCT07232719 and NCT07035093, are currently underway with much larger participant pools

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In conclusion, our novel findings reveal mechanistic complexities into the impact of IH on hippocampal adult neurogenesis

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Abbreviations AF: Annulus fibrosus ASC: Adipose-derived stem cell BMP-2: Bone morphogenetic protein-2 BMSC: Bone marrow-derived stem cell CD: Chondrodystrophic CLC: Chondrocyte-like cell CTGF: Connective tissue growth factor DH: Disc height ECM: Extracellular matrix EP: End plate GAG: Glycosaminoglycan GDF-5: Growth and differentiation factor-5 IGF-1: Isulin-like growth factor-1 IVD: Intervertebral disc MSC: Mesenchymal stromal (stem) cells MMP: Matrix metalloproteinase MRI: Magnetic resonance imaging NC: Notochordal cell NCCM: Notochordal cell conditioned medium NCD: Non-chondrodystrophic NP: Nucleus pulposus NPPC: Nucleus pulposus progenitor cell

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