Women are more susceptible than men to statin-induced decrements in DHA -3 fatty acid and mitochondrial complex activity Our studies in mice indicated that sex-biased reduction in DHA levels after statin treatment is a determinant of adverse effects in females, and that fish oil complementation prevents glucose intolerance, reduced oxidative tone, and impaired mitochondrial activity
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5.3 Antioxidant therapy Under the hypoxic environment, the rational application of antioxidants, including vitamin C, vitamin E, and N-acetylcysteine (NAC), with meticulous consideration of optimal dosage, combination, and timing of administration, exhibited remarkable antioxidant synergism, effectively mitigating cellular damage inflicted by free radicals, thereby preserving cellular integrity and health (238)
Systemic lupus erythematosus, the most common and severe form, can affect virtually any organ system in the body
Limitations of the study include the lack of medium- and long-term follow-up and the exclusive inclusion of women, which limits the generalizability of the findings
