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Funding National Natural Science Foundation of China, 82405296, 82274483, 82305158 Ethics declarations Ethics approval and consent to participate The animal study protocol was approved by the Animal Care and Use Committee (ACUC) of [Nanjing University of Traditional Chinese Medicine], protocol number [ACU240404]

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Overdose with acetaminophen causes massive necrosis of the liver tissue, which releases a protein that results in leakage of bacteria from the gut into the bloodstream (10)

Without maintenance, the improvement typically diminishes gradually over 24 months as natural melanin production resumes