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138 However, excessive or chronic inflammation exhausts immune cells due to the constant exposure of T antigens, causing dysfunction with the maintained expression of inhibitory receptors such as PD1 and CTLA4, which alter transcription

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Mediated by the pulmonary mucosa, these treatments can often be optimized, and even enabled, by managing and improving mucosal barrier function 10

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In general, mycotoxin exposure is more likely to occur in parts of the world where poor methods of food handling and storage are common, where malnutrition is a problem, and where few regulations exist to protect exposed populations