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Adipokines modulate neutrophil behavior: leptin, for instance, primes neutrophils for enhanced ROS release, delayed apoptosis, and increased degranulation, thereby creating a granulocyteadipokine feedback loop that drives tissue inflammation and metabolic dysfunction

Also gender differences were found in elderly after Spirulina consumption, with increase of IL-2 and SOD in female and decrease of IL-6 accompanied by increase in TAS in males [99]

In contrast, inhibition of TREM1 has also demonstrated protective effects in mouse models of neurodegenerative diseases (Wilson et al., 2024)

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These findings collectively highlight that PTSD is associated with reproducible patterns of gut dysbiosis, characterized by reduced SCFA-producing taxa and increased inflammatory pathobionts, supporting a functional link between microbial imbalance and psychiatric vulnerability