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In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself

It also depends on how deficient you are already

Irish journal of medical science, 193 (3), 16211639

Clinicians administering the combination have not reported any adverse interaction effects beyond the individual side effects of each compound

Vitamin B12 injections restore healthy vitamin B12 levels in people with a deficiency