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Nicotinamide (niacinamide) does not cause flushing and has fewer side effects, with nausea and liver toxicity reported only at very high intakes ~3 g/day)

The effects vary depending on individual needs, but the overall results are positive and consistent

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For observational studies (cohort and case-control), the NewcastleOttawa Scale (NOS) (La Torre et al., 2014), was applied