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It remains banned in professional sports by the World Anti-Doping Agency (WADA) but is available for research purposes and in select wellness clinics

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This decrease was more pronounced when adipocytes from HSL-null mice were utilized, a finding that suggests cooperativity exists between the two enzymes, and indeed, a synergistic effect has been observed on lipolysis when cells are cotransfected with both desnutrin/ATGL and HSL (144)

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Inhibition of NNMT has been shown to reduce fat accumulation and increase energy expenditure in preclinical models