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The absence of specialized literature refers to the lack of biochemical and signaling knowledge mechanisms regarding the immunomodulatory effects in mammals, except for a few species used in laboratory studies

[38, 39, 40, 41] This approach produces neutralizing antibodies (nAbs) against these proinflammatory biomolecules to inhibit their activities

After two washes with cold PBS, the cells were suspended in 195 L of binding buffer

Zonulin reduces the expression of intestinal TJ proteins, induces T-cell-mediated mucosal inflammation and controls the transmigration of immune cells from the gut into the joints

From a scientific perspective, the next critical step would be rigorous, independent, international clinical trials with proper controls, blinding, and standardized outcome measures