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2010;16(3):BR81-88

miltiorrhiza regulate the system Xc -GSH-GPX4 axis to induce ferroptosis

In order to further investigate the potential of three-pathway combinatorial biosynthesis of GSH, we compared utilization and conversion efficiency of amino acid precursors of engineered strain W303-1b/FGP with that of strain W303-1b/F in shake flask cultures

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Upon preincubation of the cancer cells with the antioxidant NAC and subsequent treatment with NP4, the GSH/GSSG ratio was significantly less influenced, reaching a GSH/GSSG ratio of 0.71 (Fig