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In reverse mode NET causes an efflux of the cytoplasmic pool of presynaptic norepinephrine into the synaptic cleft, where it can activate postsynaptic -1 and -1 receptors to elevate systemic vascular resistance and stimulate cardiac output (Vansal & Feller 1999

Supports cardiovascular health*

Extracellular matrix studies: Examination of collagen-associated processes

In another study using rabbit disc explants, a traumatic disc event without structural damage to the NP, AF and endplate caused transcriptional up-regulation of pro-inflammatory cytokines and catabolic enzymes

Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity