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Chien KS, Borthakur G, Naqvi K, Daver NG, Montalban-Bravo G, Cortes JE, DiNardo CD, Jabbour E, Alvarado Y, Andreeff M , Bose P, Jain N, Sheppard K, Klingner-Winton C, Pierce SA, Dong XQ, Soltysiak KA, Kantarjian HM, Garcia-Manero G

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The inhibition of ORMDL3 prevents Alzheimers disease through ferroptosis by PERK/ATF4/HSPA5 pathway

Under chronic stress, this feedback loop may degrade over time