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The performance of the mannitol excretion test in other disease conditions and treatments will need to be evaluated and compared against the multitude of studies using a combined assessment of lactulose and mannitol excretion (13)

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As indicated in Figure S4A , in the region of the graph above the lines, Niclosamide is in solution, predominantly as Nic -ve the negatively charged salt (up to its solubility limit, measured later to be 640M at pH 9.5)