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The transition from the lipid environment of the BBB endothelial cell membrane to the aqueous interstitial fluid of the brains extracellular space necessitates further consideration of a drug and its delivery vehicles physicochemical properties, including size, surface charge, shape, and molecular weight (Sykova and Nicholson, 2008

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doi: 10.1111/j.1750-3639.2004.tb00089.x

Glutathione plays a key role in neutralizing free radicals, reducing oxidative stress, and detoxifying the body

Future studies should emphasize comprehensive mechanistic validationsuch as gene-level modulationalongside in vivo efficacy testing and translational assessments, including pharmacokinetic profiling and toxicological evaluation