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In turn, the same haplotype in the Han Chinese ethnic group, constitutes a high-risk factor for the occurrence, with the use of allopurinol, of other reactions such as Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN) and DRESS syndrome.11 Thus, the same HLA alleles can cause different adverse reactions with the same medication, in different ethnicities, or with different medications, in the same population (Table 2)

Sosne, G., Rimmer, D., Kleinman, H., & Ousler, G

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GPx1 achieves its function by using two molecules of glutathione as cofactors which are ultimately reduced to glutathione disulfide in a two-step process [10]