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Considering the retrospective nature of the study, informed consent was not required, and patient data were used anonymously

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In details, serum separated, aliquoted and stored at -80 C within 1 h of venipuncture

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Aberrant methylation of DNA and proteins, which causes alterations in chromatin structure and gene expression, are a common feature of cancer cells

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DNA methylation and histone modifications: teaming up to silence genes

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