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Author contributions FL: Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing original draft, Writing review and editing

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Our results align with previous studies showing that caffeine increases BDNF expression in the hippocampus (Sallaberry et al

In melanoma, downregulation of IGF-1 reduces the dry character of melanoma initiating cells, including the expression of dry markers (SOX2, Oct-3/4, CD24 and CD133) and functional properties (melanosphere formation, aldehyde dehydrogenase activity and side population) and eventually inhibiting the proliferation and metastasis of tumor cells (26)

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