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Two noncanonical c-Myc binding sites (CACATG, E box) are present in the human GCLC promoter at 559/554 and 500/495 and together with ARE4, are responsible for H 2 O 2 -induced GCLC promoter activity (Benassi et al., 2006)

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Many studies have further demonstrated that abiotic/abiotic stress factors such as heavy metal, drought, water, heat, cellular H 2 O 2 level, oxidative state of the cell could increase the expression of APX genes to either suppress or eliminate the stressors (Ishikawa and Shigeoka, 2008