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doi: 10.1023/a:1024483520560

Less urgent but still worth reporting: side effects that do not improve after seven days at any dose level, persistent diarrhea that interferes with daily activities, significant hair thinning (which can occur during rapid weight loss phases and may relate to nutritional deficiencies rather than medication directly), mood changes including increased anxiety or depression, and hair loss patterns that seem disproportionate to weight loss speed

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These compounds were described not only as substrates for glutathione production but also as metabolically active participants in pathways related to methylation and redox signaling

Data preprocessing methods like convolutional smoothing, standard normal variable transformation, and multiplicative scatter correction are employed to optimize spectral data, enhancing the reliability of the detection models (Gao et al., 2025)