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Estrogen decline is consolidated, the growth hormone axis has dropped further, and sarcopenia plus bone density loss become primary risks rather than emerging ones

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The literature thus shows a convergence in outcome (enhanced stability/bioavailability) despite different techniques, with any divergences largely explained by mechanism: each nanocarrier system leverages a particular physicochemical principle (small droplet size, crystalline fat barrier, or polymer film) to protect and deliver lipids

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Oral and topical forms show benefits, but results vary by individual and skin color