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DEGs were identified based on the RNA-seq data

, Parklak, W

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Lasers emit targeted light energy that: Session 1: Pigmentation starts to noticeably decrease Sessions 2-4: Skin tightness and progressive lightening Full results: visible three to six months after completing the suggested sessions Laser treatment for dark circles is particularly effective for brown, pigment-driven dark circles

Validate key regulators (e.g., cell type-specific lncRNAs and lipid metabolic enzymes) using kidney organoid models, particularly patient-derived organoids (PDOs) that recapitulate disease-specific phenotypes (e.g., diabetic nephropathy and focal segmental glomerulosclerosis)