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Notably, the pK of the resulting metal-NA complexes as well as the pH of the solution (with most metals being chelated at neutral or basic pH values) were considered to significantly control the ability of NA to chelate metals (Relln-lvarez et al., 2008)

Free radicals can damage cells and cause chronic diseases like cancer, heart disease, and neurological disorders (131)

Persistent and uncontrolled oxidative stress and exacerbating NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation during severe COVID-19 disease (Lage et al., 2022), induce production of pro-inflammatory cytokines, such as IL-1 and IL-18, that can be explained because of sharply decreased macrophage GSH intracellular levels associated with increased GSH efflux (Zhang T