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This leads to cellular iron overload and induces ferroptosis ( 2+ can be released from heme through the activation of heme oxygenase-1 (HO-1), thereby accelerating ferroptosis ( vs

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Quercetin is detected in many botanical drugs and has been used to improve bleomycin (BLM)-induced PF, alter the expression levels of hydroxyproline, fibronectin, -smooth muscle actin, Collagen I, and Collagen III, and inhibit SphK1/S1P signal transduction (Zhang et al., 2018)

A study in older women found that drinking a high-flavanol cocoa drink each day increased skin elasticity