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The joint-years metric fails to capture differences in potency, device efficiency, or smoking topography, while secular increases in THC and shifts in the THC:CBD ratio complicate comparisons with earlier cohorts (57)

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F/up2) to acquire details about 1) their respiratory symptoms, 2) smoking status and conventional cigarette consumption per day (cig/day), 3) the number of severe COPD exacerbations in the prior 12 months, 4) post-bronchodilator lung function parameters (forced expiratory flow in 1 second [FEV 1 ]