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Tobacco use remains one of the worlds most devastating public health threats, claiming more than 8 million lives every yearover 7 million from direct use and around 1.3 million from exposure to secondhand smoke

FIGURE 6 Intra-group correlation analysis was performed within the 47 differential metabolites associated with the 7 metabolic pathways, and further inter-group correlation analysis was performed between these 47 differential metabolites and the top 10 microorganisms (Figure 7)

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