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Pigment Cell Melanoma Res 34(6):10001014 Charoo NA (2022) Hyperpigmentation: looking beyond hydroquinone

2021;321(1):G11-g7

38 It is known, however, that the major zinc-sensing transcription factors in eukaryotic cells, exemplified by vertebrate MTF-1 and Zap1p in Saccharomyces cerevisiae (Figure 3B) employ one or more ZF motifs as sensors of cellular zinc status, which results in the regulation of transcription of genes that encode enzymes that re-establish zinc homeostasis

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Moreover, combining it with collagen offers additional skin hydration, which supports glutathiones brightening effect