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Also in this setting, the potency of FOXO4-DRI was more pronounced when applied in consecutive rounds Not only did FOXO4-DRI selectively target the senescent cells, but it was also effective agains the induced chemo-toxicity observed in the form of liver toxicity and body weight loss

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The psychological impact of visible cosmetic improvements should not be underestimated in maintaining motivation throughout lengthy protocols

Topical creams with menthol or capsaicin can provide localized relief without systemic effects