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The basal diet did not contain any GSH

The unique pharmacological profile of tirzepatide allows a greater engagement of the GIP receptor, mimicking the actions of native GIP, compared to the GLP-1 receptor, where it activates biased downstream signals favoring cAMP generation over beta-arrestin recruitment, resulting in reduced receptor internalization and degradation 2

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In contrast, ironsulfur cluster-binding glutaredoxins such as ScGrx3-5 have a modified loop and helix 3 (Fig