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Changes in Blood Profile from Steady State in Patients with Sickle Cell Anemia Admitted for Vaso-occlusive Crisis and Acute Chest Syndrome

CAMMS223 Trial Investigators

Since all the fragments crystallized in subpocket C contained HEPE moiety with an additional polar substituent, it was tempting to think that a similar polar moiety should be placed in subpocket C

Additionally, catabolism occurs through cystathionine beta-synthase, leading to the formation of cystathioninea non-noxious product that further converts into cysteine