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Despite technological improvements and advances in the standards of postoperative care, many deficiencies are still encountered in the use of AVF related to its high incidence of failure due to unsuccessful maturation to adequately support HD and the development of neointimal hyperplasia (NIH), which narrows the AVF lumen

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These gene variants affect key physiological processes such as insulin secretion, insulin signaling pathways, pancreatic -cell function, and energy metabolism, thereby increasing the risk of developing T2D

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