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Treatment duration should always be individualized under medical supervision rather than following arbitrary timelines

Therefore, although our review aimed to broaden our knowledge on the clinical applications of ALA, further randomized, double-blind, placebo-controlled clinical trials with adequate sample sizes, homogeneity of population studied, statistical power, as well as longer duration are (still) needed to confirm the clinical benefit of this multifunctional compound and extend its use in routine medical practice

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