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It was discovered more than 60 years ago that tumor cells had a unique capacity to display reduced rates of respiration, which typically cause the death of healthy cells, together with increased glycolysis and pentose phosphate cycle activity ( Figure 2 )

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Within this dimer, MC3R-associated cAMP accumulation is increased twofold while GHSR1a constitutive activity and ghrelin-induced activity, as measured by intracellular Ca 2+ levels, are reduced by 40% (Fig

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