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Nanomedicines for cancer therapy: state-of-the-art and limitations to pre-clinical studies that hinder future developments

These electron-electron repulsions affect the Coordination number: When a ligand donates its electrons to a metal center to form a new metal-ligand bond, the electron density around the metal increases, raising the overall energy of the other M-L bonding electrons

Additionally, the enhancement of serine synthesis pathway in NRF2-addicted cancer cells (DeNicola et al

Corilagin induces apoptosis and autophagy in NRF2-addicted U251 glioma cell line

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