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Therefore, the alteration of Wnt and its related gene copy number in cfDNA can be used to diagnose CRC

Beyond this classic signaling pathway that is widely implicated in tumorigenesis, GGCT could also regulate the Notch-Akt axis to facilitate the uncontrolled proliferation and aggressive growth of glioma cells [14]

Further prospective studies with larger patient groups and research evaluating drugs with antidepressant and antioxidant effects capable of reducing oxidative stress are now needed to confirm our results and to shed light on the underlying mechanisms

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