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Such modifications can result in loss of enzymatic activity, altered cellular signaling, and degradation of structural proteins, contributing to cellular dysfunction and death [36, 37]

Especially in GC, the down-regulation of NCOA4, the core receptor for ferritin phagocytosis, has been found to be a key driver of peritoneal metastasis

Dec 2008;30(6):543-545

All complexes were cryoprotected using the respective mother liquor solution supplemented by 5% glycerol and peptide at the corresponding concentration

Therefore, evaluating the safety of these prodrug-based nanomedicines is also an important factor in transitioning from basic to clinical application