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Specifically, the generation of ceramides by dihydroceramide desaturase 1 (DES1) in adipocytes seems to impart some of the lipotoxic effects such as impaired glucose utilization, insulin resistance and hepatic steatosis (198)

NNMT is expressed abundantly in adipose tissue, where it has been associated with fat cell size and lipid storage dynamics

Unlike full-length growth hormone, AOD-9604 selectively stimulates lipolysis without significantly affecting blood glucose levels or growth pathways, making it a valuable tool for studying adipocyte function, fat metabolism, and energy regulation