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Uncontrolled levels of oxidative stress may lead to inflammation, accelerate aging and facilitate the development of chronic conditions

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In addition to the up-regulation of cytoskeletal proteins in platelets from -thalassemia/HbE patients, we observed the up-regulation of integrin, a transmembrane receptor protein that acts as a bridge between the extracellular matrix and the cytoskeletal membrane that mediates signal transduction in activated platelets, resulting in platelet shape changes and platelet aggregation 22

doi: 10.1096/fj.05-4985fje

The acute form of the disease is characterized by the sudden onset of cardiac insufficiency, while the chronic form results in moderate-to-severe heart enlargement with varying degrees of cardiac insufficiency (52)