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Most of the anabolic and tissue-remodeling effects attributed to IGF-1 signaling run through one or both of these

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These observations underscore an important therapeutic implication for MASLD, showing that the timing and disease stage may be critical for maximizing the protective effects of GSH depletion, with the greatest benefit likely occurring during early, lipogenesis-driven phases of MASLD progression

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87 Thus, high GSH may reduce the mutation rate in genes encoding drug targets such as ribosomal proteins or DNA gyrase

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