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Several cross-sectional and casecontrol studies revealed that a higher concentration of carotenoids in blood is associated with a thinner wall of carotid arteries (Rissanen et al

Eur J Pharmacol 147:321326, 1988 Hernandez DE, Walker CH, Valenzuela JE, Mason GA: Increased dopamine receptor binding in duodenal mucosa of duodenal ulcer patients

Route differences introduce pharmacokinetic variables (Tmax, Cmax, AUC) that make direct efficacy comparisons unreliable

NOS1 and NOS3 exhibit Ca-dependent activity and are expressed in striated muscle and endothelial cells

Nonetheless, higher doses (2,7004,500 mg/kg) induced some behavioral changes in rats, such as aggressive scratching, anorexia, mild restlessness, and increased sensitivity to sound