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NAD depletion by FK866 induces autophagy

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Dietary factors, such as polyunsaturated fatty acids (PUFA), fiber as well as the intake of Mediterranean diet appear to exert beneficial effects on female reproductive outcomes

Aside from its effects on cell death, autophagy, apoptosis, and pyroptosis, p53 is also involved in regulating cell ferroptosis

As the disease progresses to stage 3, systemic hyperphosphatemia typically arises, further exacerbating systemic inflammation and vascular calcification, and consequently accelerating the process of early vascular aging (Voelkl et al., 2018)