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Cells were plated in rows BG and columns 210, with 100l DMEM or Hanks Balanced Salt Solution (HBSS) plated in remaining wells

According to reports, curcumin is a P450 inhibitor that inhibits CYP2C9, CYP1A2, CYP2D6, CYP2B6 and CYP3A4, with particularly low IC50 values for CYP2C9 (Sasaki et al., 2017)

10.14814/phy2.13182 Physiol Rep

Similar, although less pronounced profile of Akt activation has been established upon GSB-106 exposure: a moderate stimulation of Akt phosphorylation at 30 min with a consequent kinase activation decline at a later time point