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Research does not appear to support this theory

But why is that

Cotinine is of paramount importance in the context of tobacco exposure for several compelling reasons: Accurate Detection: Cotinine serves as a highly reliable biomarker for detecting nicotine and, by extension, tobacco exposure

(1985) of results of a study of smokers showing that a transdermal nicotine patch reduced craving for cigarettes

Though Poole-as-Warburton argues that up to snuff was referring to Hamlets ability to literally sniff out Rosencrantz and Guildensterns ulterior motive, Poole-as-Johnson asserts that it was likely being used in its common acceptation as a reference to Hamlets being a knowing one. Grose's Classical Dictionary of the Vulgar Tongue echoed Poole-as-Johnsons understanding of the phrase in its 1823 edition, and so did Merriam-Webster in its 1864 dictionary