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The use of systems toxicology to generate toxicity data on IQOS was unique to PMI studies, and several initiatives were taken to validate the utility of this approach (Figure 3) 114

The cavendish is there to allow the flavoring to lead the way

Public Health 27 , 5662 (1999)

However, we routinely work with elite commercial cultivars including K326, yun87, CB-1, and various Burley and Oriental lines

A tobacco product is defined as "any product made or derived from tobacco that is intended for human consumption, including any component, part, or accessory of a tobacco product (except for raw materials other than tobacco used in manufacturing a component, part, or accessory of a tobacco product)." 11 Any article that is a drug, device, or combination product (a combination of a drug, device, or biological product) is excluded from the definition of tobacco product