CYPs also contribute to steroid metabolism in several extra-hepatic tissues, including the brain, breast and prostate [[126], [127], [128], [129]]
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Regional neurochemical profiles in the human brain measured by (1)H MRS at 7 T using local B(1) shimming
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These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints ( In most cases, joint pain is due to damage to the articular cartilage