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This limitation has been addressed by increasing serum UA in various ways, both pharmacological and genetic, including knockout of the uricase gene

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Its side chain is similar to that of glutamic acid, except the carboxylic acid group is replaced by an amide

Treatment with 5-amino-1mq upregulates proliferationrelated genes (Ki67, PCNA), promotes cell cycle progression, and improves cell fusion efficiency to form more multinucleated myotubes, achieving functional levels similar to those of young mice.Additionally, 5-amino-1mq inhibits muscle stem cell apoptosis, reduces oxidative stress damage, and maintains stemness

Lower CGA concentrations (50300 M) decreased LDH activity in L-02 cells ( p 0.05) (Figure 7D)