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According to a study published in Frontiers in Pharmacology, intramuscular administration of vitamin B12 produces a faster increase in serum levels compared to oral routes, although both methods are effective in restoring normal cobalamin levels in patients with deficiency

Serum B12 levels confirm B12 deficiency

However, it never received FDA approval because the results, while positive, weren't dramatic enough to meet regulatory thresholds for an obesity drug

Theyre convenient and generally affordable, but their effectiveness largely depends on your bodys ability to absorb them

IV doses of 25-400 mcg/kg for safety studies Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, pharmacokinetics, receptor expression, peptide degradation rates, and tissue distribution patterns