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Types of B12: The most common forms are cyanocobalamin (a stable, synthetic form) and methylcobalamin (an active form)

The decline in oestrogen appears to remove a layer of protection, which in turn accelerates depletion of this critical molecule, creating a cycle that worsens symptoms

Available from: Hibler EA, Zhu X, Shrubsole MJ, Hou L, Dai Q

A sudden rise in O-GlcNAcylation reduces GABAergic currents in principal cells of the rodent hippocampus, thereby disrupting the excitation/inhibition balance, a characteristic feature observed in SZ [47]

The first step in treatment is a thorough skin examination to determine what type of melasma you have: epidermal (superficial), dermal (deep), or mixed