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Int J Devl Neurosci 47:259265 Derks TGJ, Touw CML, Ribas GS et al (2014) Experimental evidence for protein oxidative damage and altered antioxidant defense in patients with medium-chain acyl-CoA dehydrogenase deficiency

Every time your cells divide, these telomeres get slightly shorter

It creates a chronic pro-oxidant environment that overwhelms the already-depleted GSH-based antioxidant network in diabetic patients

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A similar situation was observed in rbohD mutants of Arabidopsis, also exhibiting decreased apoplastic localization (Otulak-Kozie et al., 2023)