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Clinical trials have used doses of 25-30 nmol/kg by IV infusion (Schneider-Helmert et al., 1981Subcutaneous administration and oral intestinal absorption have also been studied

By extrapolating complex scenarios observed in vitro while having in mind that intrinsic and extrinsic factors can alter the kinetic values, one can identify optimal dosing regimens for individual patients (Rostami-Hodjegan 2012

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the BMDL value of E Cd /C cr leading to a 5% reduction in eGFR was 0.0215 g/L of filtrate for both men and women [47]