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The activated Nrf2 promotes the transcription of antioxidant enzymes, including quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO-1), and microsomal epoxide hydrolase, and further promotes GSH synthesis ( Once activated, the p53 tumor suppressor protein promotes cell survival and repairs genetic damage in response to various stress, such as cellular stress and DNA damage

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